R65.11
Billable codeSystemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
The ICD-10 code for systemic inflammatory response syndrome (sirs) of non-infectious origin with acute organ dysfunction is R65.11.
Clinical notes
Use additional code
This code represents an underlying condition. When a related manifestation is also present, coding convention calls for an additional code to be listed after this one.
- code to identify specific acute organ dysfunction, such as:
- acute kidney failure (N17.-)
- acute respiratory failure (J96.0-)
- critical illness myopathy (G72.81)
- critical illness polyneuropathy (G62.81)
- disseminated intravascular coagulopathy [DIC] (D65)
- encephalopathy (metabolic) (septic) (G93.41)
- hepatic failure (K72.0-)
Documentation support
General coding-documentation guidance — not a substitute for payer-specific requirements or professional coding judgment.
- •If the associated manifestation or related condition noted above is also documented, an additional code should be reported alongside this one.
- •As a general rule, code to the highest level of specificity supported by the documentation in the medical record.
Related codes in this category
- R65.10Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
- R65.11Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
ICD-9-CM equivalent
Informational only — GEM mappings are approximate, not guaranteed one-to-one equivalents. Verify before use in billing.
- 99594
Associated MS-DRGs
R65.11 can serve as the principal diagnosis for these Medicare Severity Diagnosis-Related Groups.
Informational only — actual DRG assignment also depends on procedures, complications/comorbidities (CC/MCC), discharge status, and payer-specific rules not reflected here.